Potassium Hydroxide → HCID 86751917, compound

Participants

Reaction Steps

A The reaction is carried out in a way analogous to that described in Example 3, but from 3.6 g of tert-butyl (2RS,4RS,5SR)-1-{2-[3-(3-(methoxycarbonyl)phenyl)ureido]acetyl}-4-methylphenylcarbamoyl-5-phenylpyrrolidine-2-carboxylate and 0.33 g of potassium hydroxide in a mixture of 20 cm3 of distilled water and 60 cm3 of methanol. After treatment, there are obtained 1.1 g of (2RS,4RS,5SR)-3-{3-[2-(2-tert-butoxycarbonyl-5-phenyl-4-methylphenylcarbamoyl-1-pyrrolidinyl)-2-oxoethyl]ureido}benzoic acid, melting at 238° C.

Provenance & Evidence