Sodium Carbonate → HCID 19710000, compound

HRID 725893Notes

Reaction equation

HRID 725893 reaction equation
C[O:2][C:3]1[C:11]2[O:10][C:9]([C:12]3[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=3)=[CH:8][C:7]=2[CH:6]=[CH:5][CH:4]=1.[OH-].[Na+].C([O-])([O-])=O.[Na+].[Na+]>Br>[OH:2][C:3]1[C:11]2[O:10][C:9]([C:12]3[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=3)=[CH:8][C:7]=2[CH:6]=[CH:5][CH:4]=1

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 14798Sodium HydroxideHCID 22733883HCID 22733883, compound

Product 1

HCID 19710000HCID 19710000, compound

Reagents, catalysts & solvents 1

HCID 260Hydrogen BromideSolvent

Procedure

A mixutre of 4-(7-methoxy-2-benzofuranyl)pyridine (5.0 g) and 48% HBr (50 ml) was stirred at 120° C. for 1 hour. The mixture was cooled to room temperature, neutralized with 10% NaOH and 5% Na2CO3 and extracted with ethyl acetate. The organic extract was washed with brine and concentrated to give 4-(7-hydroxy-2-benzofuranyl)pyridine.

Workup

  1. extractionextracted with ethyl acetate
  2. extractionThe organic extract
  3. washwas washed with brine
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-aebb503fa9d540098597d835aeba0282
Source dataset
uspto-grants-1998_01
Patent number
US05708007

Reaction notes

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