HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Trifluoroacetate → 5-Trifluoromethyl-2-(di-n-propylamino)indan
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Trifluoroacetate | HCID 517019 | — |
| Reactant | (6-Bromo-indan-2-yl)-dipropyl-amine | HCID 21221814 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Solvent | 1-Methyl-2(1H)-pyridinone | HCID 12755 | — |
| Product | 5-Trifluoromethyl-2-(di-n-propylamino)indan | HCID 19710230 | — |
Reaction Steps
A solution of 5-bromo-2-(di-n-propylamino)indan (Example 11), sodium trifluoroacetate, and copper (I) iodide in N-methylpyridone is heated at 160° C. for 4 h under nitrogen (Chem Lett 1981, 1719). The reaction mixture is cooled to room temperature and diluted with ethyl acetate. The mixture is filtered through a layer of Celite pad and the filtrate is washed with water, brine, dried (MgSO4), filtered, and concentrated. The oil is purified by liquid chromatography to give the title compound as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05708018 |
| Source dataset | uspto-grants-1998_01 |
| ORD ID | ord-99091c0fa8264508863a54a7df4c6f40 |
| Source note | uspto-grants-1998_01 |