反应详情

A solution of 5-bromo-2-(di-n-propylamino)indan (Example 11), sodium trifluoroacetate, and copper (I) iodide in N-methylpyridone is heated at 160° C. for 4 h under nitrogen (Chem Lett 1981, 1719). The reaction mixture is cooled to room temperature and diluted with ethyl acetate. The mixture is filtered through a layer of Celite pad and the filtrate is washed with water, brine, dried (MgSO4), filtered, and concentrated. The oil is purified by liquid chromatography to give the title compound as a yellow oil.

1. filtrationThe mixture is filtered through a layer of Celite pad
2. washthe filtrate is washed with water, brine
3. dry with materialdried (MgSO4)
4. filtrationfiltered
5. concentrationconcentrated
6. customThe oil is purified by liquid chromatography