反应详情

To a solution of 5-trifluoromethanesulfonyloxy-2-(di-n-propylamino)indan (Example 2) in 1,4-dixoane is treated with tri-n-butylethynylstannane, lithium chloride, tetrakis(triphenylphosphlne)palladium(0), and a few crystals of 2,6-di-tert-butyl-4-methylphenol under nitrogen (J. Am. Chem. Soc. 1987, 109, 5478). The mixture is refluxed for 6 h, cooled to room temperature, and treated with pyridine and pyridine fluoride and iluted with diethyl ether. The resulting crude product is purified by chromatography to give the title compound.

1. temperatureThe mixture is refluxed for 6 h
2. customThe resulting crude product is purified by chromatography