2,6-Di-tert-butyl-4-methylphenol → HCID 19710197, compound

Participants

Reaction Steps

To a solution of 5-trifluoromethanesulfonyloxy-2-(di-n-propylamino)indan (Example 2) in 1,4-dixoane is treated with tri-n-butylethynylstannane, lithium chloride, tetrakis(triphenylphosphlne)palladium(0), and a few crystals of 2,6-di-tert-butyl-4-methylphenol under nitrogen (J. Am. Chem. Soc. 1987, 109, 5478). The mixture is refluxed for 6 h, cooled to room temperature, and treated with pyridine and pyridine fluoride and iluted with diethyl ether. The resulting crude product is purified by chromatography to give the title compound.

Provenance & Evidence