Hydrochloric Acid → HCID 19710212, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 5-trifluoromethanesulfonyloxy-2-(di-n-propylamino)indan (Example 2) in DMF is treated sequentially with triethylamine, butyl vinyl ether, 1,3-bis(diphenylphosphino)propane, and palladium acetate under nitrogen. The mixture is heated at 80° C. for 0.5 h. (J. Org. Chem. 1990, 55 3654). The reaction mixture is cooled to room temperature and treated with 5% HCl. After stirring for 0.5 h, the mixture is extracted with methylene chloride. The crude product is purified by chromatography to yield the title compound.

Provenance & Evidence