反应详情

温度

80 °C

To a solution of 5-trifluoromethanesulfonyloxy-2-(di-n-propylamino)indan (Example 2) in DMF is treated sequentially with triethylamine, butyl vinyl ether, 1,3-bis(diphenylphosphino)propane, and palladium acetate under nitrogen. The mixture is heated at 80° C. for 0.5 h. (J. Org. Chem. 1990, 55 3654). The reaction mixture is cooled to room temperature and treated with 5% HCl. After stirring for 0.5 h, the mixture is extracted with methylene chloride. The crude product is purified by chromatography to yield the title compound.

1. temperatureThe reaction mixture is cooled to room temperature
2. extractionthe mixture is extracted with methylene chloride
3. customThe crude product is purified by chromatography