HCID 19710195, compound → HCID 19710255, compound

HRID 725931Notes

Reaction equation

HRID 725931 reaction equation
[C:1]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][C:13]=1[O:14][CH3:15])[CH2:10][CH:9]([N:16]([CH2:20][CH2:21][CH3:22])[CH2:17][CH2:18][CH3:19])[CH2:8]2)(OC)=[O:2].[H-].[Al+3].[Li+].[H-].[H-].[H-]>C1COCC1>[OH:2][CH2:1][C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][C:13]=1[O:14][CH3:15])[CH2:10][CH:9]([N:16]([CH2:17][CH2:18][CH3:19])[CH2:20][CH2:21][CH3:22])[CH2:8]2

Participants

4

Reactant 2

HCID 19710195HCID 19710195, compoundHCID 21226445Aluminium lithium hydride

Product 1

HCID 19710255HCID 19710255, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 5-carbomethoxy-6-methoxy-2-(di-n-propylamino)indan (Example 57) in THF at 0° C. under nitrogen is treated with excess lithium aluminum hydride. After work-up and purification, the title compound is obtained.

Workup

  1. customAfter work-up and purification

Sources & evidence

ORD record
ord-e8de7008dac84132a66c94ac369fab04
Source dataset
uspto-grants-1998_01
Patent number
US05708018

Reaction notes

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