Dimethylcarbamoyl Chloride → HCID 22611361, compound

HRID 725997Notes

Reaction equation

HRID 725997 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:11]1[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]1.[CH3:18][N:19]([CH3:23])[C:20](Cl)=[O:21]>>[CH3:18][N:19]([CH3:23])[C:20]([NH:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:11]1[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]1)=[O:21]

Participants

3

Reactant 2

HCID 6598Dimethylcarbamoyl ChlorideHCID 118312203-(1-Methylpiperidin-4-yl)-1h-indol-5-amine

Product 1

HCID 22611361HCID 22611361, compoundYield 79%

Procedure

Beginning with 13.0 mg (0.056 mMol) 5-amino-3-(1-methyl-piperidin-4-yl)-1H-indole and 6.4 mg (0.059 mMol) dimethyl carbamoyl chloride, 13.2 mg (79%) of the title compound were recovered.

Sources & evidence

ORD record
ord-9157f15049e34c11a2196a3a53b4255d
Source dataset
uspto-grants-1998_01
Patent number
US05708008

Reaction notes

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