Picolinic acid → HCID 22611638, compound

HRID 726058Notes

Reaction equation

HRID 726058 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:11]1[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]1.[N:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[C:24](O)=[O:25]>>[N:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[C:24]([NH:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:11]1[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]1)=[O:25]

Participants

3

Reactant 2

HCID 1018Picolinic acidHCID 118312203-(1-Methylpiperidin-4-yl)-1h-indol-5-amine

Product 1

HCID 22611638HCID 22611638, compoundYield 85%

Procedure

Beginning with 12.0 mg (0.05 mMol) 5-amino-3-(1-methylpiperidin-4-yl)-1H-indole and 19.0 mg (0.15 mMol pyridine-2-carboxylic acid, 14.2 mg (85%) of the title compound were recovered.

Sources & evidence

ORD record
ord-3358e2c132634f95b43838a4b05e204a
Source dataset
uspto-grants-1998_01
Patent number
US05708008

Reaction notes

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