2-Pyrazinecarboxylic acid → HCID 22611614, compound

HRID 726062Notes

Reaction equation

HRID 726062 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:11]1[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]1.[N:18]1[CH:23]=[CH:22][N:21]=[CH:20][C:19]=1[C:24](O)=[O:25]>>[N:18]1[CH:23]=[CH:22][N:21]=[CH:20][C:19]=1[C:24]([NH:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:11]1[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]1)=[O:25]

Participants

3

Reactant 2

HCID 10472-Pyrazinecarboxylic acidHCID 118312203-(1-Methylpiperidin-4-yl)-1h-indol-5-amine

Product 1

HCID 22611614HCID 22611614, compoundYield 24%

Procedure

Beginning with 20.0 mg (0.087 mMol) 5-amino-3-(1-methylpiperidin-4-yl)-1H-indole and 32 mg (0.131 mMol) pyrazine-2-carboxylic acid, 6.9 mg (24%) of the title compound were recovered.

Sources & evidence

ORD record
ord-afca7e428c644d759b1bc2021ee253dc
Source dataset
uspto-grants-1998_01
Patent number
US05708008

Reaction notes

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