HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → Methyl 4-fluoro-3-(trifluoromethyl)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 4-Fluoro-3-(trifluoromethyl)benzoic acid | HCID 522268 | — |
| Product | Methyl 4-fluoro-3-(trifluoromethyl)benzoate | HCID 15285559 | — |
Reaction Steps
5 g of 4-fluoro-3-trifluoromethylbenzoic acid and 9 ml of SOCl2 are stirred at 60° C. for 8 h in 50 ml of MeOH. The volatile constituents are then removed in vacuo and 5.1 g of a colorless oil are obtained, which is further employed without purification. Rf (EA/MeOH 10:1)=0.74 MS (DCl) 223 (M+H)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05708034 |
| Source dataset | uspto-grants-1998_01 |
| ORD ID | ord-9ced113423924b26aa70e9c924ed37af |
| Source note | uspto-grants-1998_01 |