Triphenylphosphine → HCID 54372321, compound

HRID 726098Notes

Reaction equation

HRID 726098 reaction equation
[CH2:1]([N:5]([CH3:16])[C:6](=[O:15])[CH2:7][O:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13]O)[CH2:2][CH2:3][CH3:4].[Br:17]CC(Br)(Br)Br.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>C(Cl)Cl>[Br:17][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][O:8][CH2:7][C:6]([N:5]([CH2:1][CH2:2][CH2:3][CH3:4])[CH3:16])=[O:15]

Participants

5

Reactant 3

HCID 11776TriphenylphosphineHCID 611791,1,1,2-TetrabromoethaneHCID 85613375HCID 85613375, compound

Product 1

HCID 54372321HCID 54372321, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
0 °C

Procedure

To a solution of 7.2 g of the product of Step C in 73 ml of methylene chloride, there were added at -10° C. 13 g of reaction tetrabromoethane and 10.3 g of triphenylphosphine and the reaction medium was stirred for one hour at 0° C. and chromatographed on silica (eluant: ethyl acetate-cyclohexane 7-3) to obtain 7.49 g of the desired compound.

Workup

  1. customchromatographed on silica (eluant: ethyl acetate-cyclohexane 7-3)

Sources & evidence

ORD record
ord-ee7a00de087a431b8a6fc1d7d2b9ae56
Source dataset
uspto-grants-1998_01
Patent number
US05707982

Reaction notes

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