Hydrochloric Acid → HCID 22672711, compound

HRID 726109Notes

Reaction equation

HRID 726109 reaction equation
Cl.[CH2:2]([N:6]([CH3:24])[C:7](=[O:23])[C:8]#[C:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][O:15][SiH2]C(C)(C)C(C)C)[CH2:3][CH2:4][CH3:5]>>[CH2:2]([N:6]([CH3:24])[C:7](=[O:23])[C:8]#[C:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][OH:15])[CH2:3][CH2:4][CH3:5]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 123381142HCID 123381142, compound

Product 1

HCID 22672711HCID 22672711, compoundYield 69%

Procedure

1 ml of 2N hydrochloric acid was added to a solution of 1.9 g of the product of Step C and the mixture was maintained for one hour at ambient temperature, then extracted with ethyl acetate. The extracts were washed with water, dried and evaporated to dryness under reduced pressure. The 1.79 g of residue were chromatographed on silica (eluant: ethyl acetate) to obtain 870 mg of the expected product.

Workup

  1. extractionextracted with ethyl acetate
  2. washThe extracts were washed with water
  3. customdried
  4. customevaporated to dryness under reduced pressure
  5. customThe 1.79 g of residue were chromatographed on silica (eluant: ethyl acetate)

Sources & evidence

ORD record
ord-70ee462a425a4a80ab49239c110f3b2d
Source dataset
uspto-grants-1998_01
Patent number
US05707982

Reaction notes

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