Pyridine → 4-Ethoxy-1,1,1-trifluoro-3-buten-2-one

HRID 726186Notes

Reaction equation

HRID 726186 reaction equation
[CH:1]([O:3][CH2:4][CH3:5])=[CH2:2].N1C=CC=CC=1.[F:12][C:13]([F:18])([F:17])[C:14](Cl)=[O:15]>C(Cl)Cl>[CH2:1]([O:3][CH:4]=[CH:5][C:14](=[O:15])[C:13]([F:18])([F:17])[F:12])[CH3:2]

Participants

5

Reactant 3

HCID 1049PyridineHCID 8023Ethyl vinyl etherHCID 61106Trifluoroacetyl chloride

Product 1

HCID 27803954-Ethoxy-1,1,1-trifluoro-3-buten-2-one

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

In 150 ml of methylene chloride, 21 ml (0.22 mol) of ethyl vinyl ether and 26.1 g (0.33 mol) of pyridine were dissolved, and 43.8 g (0.33 mol) of trifluoroacetyl chloride was blown into this solution over a period of 30 minutes at room temperature. The mixture was further stirred at room temperature for 2.5 hours. Then, the reaction solution was extracted by an addition of 100 ml of methylene chloride and 100 ml of ice water.

Workup

  1. extractionThen, the reaction solution was extracted by an addition of 100 ml of methylene chloride and 100 ml of ice water

Sources & evidence

ORD record
ord-f4ca3ecd894e4d1d8860b36fef562ac3
Source dataset
uspto-grants-1998_01
Patent number
US05708175

Reaction notes

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