反应详情

To a solution of ethyl 4-propionamidocinnamate (160 mg) in ethanol (5 ml) was added 1N aqueous sodium hydroxide solution (1.5 ml) at ambient temperature. The mixture was stirred at same temperature for 14 hours, and then at 40° C. for 2 hours. 1N-hydrochloric acid (1.5 ml) was added to the reaction mixture and evaporated in vacuo. The residue was diluted with 10% methanol-dichloromethane, washed with water, dried over magnesium sulfate and evaporated in vacuo. The residue was crystallized from diisopropyl ether to give 4-propionamidocinnamic acid (115 mg) as a colorless powder.

1. waitat 40° C. for 2 hours
2. customevaporated in vacuo
3. additionThe residue was diluted with 10% methanol-dichloromethane
4. washwashed with water
5. dry with materialdried over magnesium sulfate
6. customevaporated in vacuo
7. customThe residue was crystallized from diisopropyl ether