反应详情

温度

55 °C

Thiophenol 2(2) (2.77 g, 0.025 mol), cesium carbonate (24.65 g, 0.075 mol) and catalytical amount of cesium fluoride were added successively to a solution of 2-chloromethylpyridine 6(1) (1.13 g, 0.017 mol) in absolute DMF (28 ml). The reaction mixture was stirred at 50-60° C. for 2 h in argon current and left for night at 20° C. Solvent was removed in vacuo, the residue was dissolved in water, the reaction product was extracted with CH2Cl2, dried over MgSO4, solvent was evaporated in vacuo. It gave 2-phenylsulphanylmethylpyridine 6(2), 3.2 g, (95%).

1. waitleft for night at 20° C
2. customSolvent was removed in vacuo
3. dissolutionthe residue was dissolved in water
4. extractionthe reaction product was extracted with CH2Cl2
5. dry with materialdried over MgSO4, solvent
6. customwas evaporated in vacuo