反应详情

1.8 g (10 mmol) of allyl 4-aminobenzoate, 50 ml of THF and 1.7 ml (12 mmol) of triethylamine were introduced into a round-bottomed flask. A solution of 3.3 g (10 mmol) of α-methoxycarbonyl-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)acetic acid chloride in 25 ml of THP was added dropwise and the mixture was stirred at room temperature for 2 hours. The reaction medium was poured into water, and extracted with ethyl acetate. The organic phase was decanted off, dried over magnesium sulfate and evaporated. The residue obtained was recrystallized from ethanol; 3.3 g (69%) of the expected compound of melting point 155°-156° C. were recovered after filtration and drying.

1. extractionextracted with ethyl acetate
2. customThe organic phase was decanted off
3. dry with materialdried over magnesium sulfate
4. customevaporated
5. customThe residue obtained
6. customwas recrystallized from ethanol
7. custom3.3 g (69%) of the expected compound of melting point 155°-156° C. were recovered
8. filtrationafter filtration
9. customdrying