1-Iodopropane → methyl N-propyl-4-nitro-2-pyrrolecarboxylate

HRID 726479Notes

Reaction equation

[N+:1]([C:4]1[CH:5]=[C:6]([C:9]([O:11][CH3:12])=[O:10])[NH:7][CH:8]=1)([O-:3])=[O:2].I[CH2:14][CH2:15][CH3:16]>>[CH2:14]([N:7]1[CH:8]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=[C:6]1[C:9]([O:11][CH3:12])=[O:10])[CH2:15][CH3:16]

Participants

Reactant 2

HCID 336431-Iodopropane

HCID 261887Methyl 4-nitro-1h-pyrrole-2-carboxylate

Product 1

HCID 18792294methyl N-propyl-4-nitro-2-pyrrolecarboxylateYield 64%

Procedure

Following the basic procedure of Example 25(d), by reacting 1.79 g (10.5 mmol) of methyl 4-nitro-2-pyrrolecarboxylate with 1.23 ml (12.6 mmol) of 3-iodopropane, 1.42 g (64%) of the expected compound was obtained.

Sources & evidence

ORD record: ord-07f1b3a29cdc420f8fed762226a1d319
Source dataset: uspto-grants-1998_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05709867

Reaction notes

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