反应详情

Treatment of 2-((6-methoxy-5-nitropyridin-3-yl)methylthio)acetic acid (1.0 mmol, 0.26 g) in acetic acid (30 mL) with hydrogen peroxide 35% (1.0 mmol, 0.05 mL) and the mixture was stirred at room temperature for 1.5 hr followed by 60° C. for 30 minutes. The mixture was evaporated in vacuo to yield the title compound. 1H-NMR (D2O) δ: 1.97 (s, 2H, CH2), 4.23 (d, 1H, J=14.0 Hz, CH), 4.44 (d, 1H, J=14.0 Hz, CH), 4.14 (s, 3H, OCH3), 8.43 (s, 1H, Py-H), 8.52 (s, 1H, Py-H); HR-MS (ESL) m/z: 273.0146 [M−H]−, C9H10N2O6S requires 274.0260.

1. customThe mixture was evaporated in vacuo