反应详情

First, 19.6 g of ethyl 4-bromobutyrate, 24.4 g of triphenylphosphine, and 70 ml of toluene were placed in a 200 ml flask. The mixture was stirred under reflux for 10 hours. After the mixture was cooled, produced crystal was recovered by filtration and washed with toluene to obtain 31.4 g of 3-ethoxycarbonylpropyltriphenylphosphonium bromide (Y: 68%). The compound thus obtained had an m.p. of 173° C. to 180° C.

1. temperatureunder reflux for 10 hours
2. temperatureAfter the mixture was cooled
3. customproduced crystal
4. filtrationwas recovered by filtration
5. washwashed with toluene