反应详情

0.3 mmol of (6-nitro-2,3-dioxo-1,2,3,4-tetrahydrobenzo[f]quinoxalin-1-yl)-methanephosphonic acid diethyl ester in 10 ml of DMF z.A. is dissolved, and 10 mg of platinum oxide catalyst, which was previously saturated with hydrogen, is added. It is hydrogenated with hydrogen for three hours at normal pressure and room temperature. The catalyst is suctioned off on Celite, the mother liquor is diluted with water and the precipitate that is produced is suctioned off. 44% of theory of (6-amino-2,3-dioxo-1,2,3,4-tetrahydro-benzo[f]quinoxalin-1-yl)-methanephosphonic acid diethyl ester is obtained. The latter is described as in Example 1e) or saponified according to standard conditions with HCl to (6-amino-2,3-dioxo-1,2,3,4-tetrahydrobenzo[f]quinoxalin-1-yl)-methanephosphonic acid (or to its hydrochloride, respectively).

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2. additionis added
3. customthe precipitate that is produced