HCID 19706968, compound → Benzaldehyde

HRID 726562Notes

Reaction equation

HRID 726562 reaction equation
[O:1]=[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)N(C2C=CC=CC=2)CN1CCO.[O:21]=[C:22]1[C:31]2[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=2)N(C)CN1CCO.[O:36]=[C:37]1[C:46]2[C:41](=[CH:42][CH:43]=[CH:44][CH:45]=2)[N:40]([C:47]2[CH:52]=[CH:51][CH:50]=[CH:49][N:48]=2)[CH2:39][N:38]1[CH2:53][CH2:54][OH:55]>>[CH:2](=[O:1])[C:11]1[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=1.[O:36]=[C:37]1[C:46]2[C:41](=[CH:42][CH:43]=[CH:44][CH:45]=2)[N:40]([C:47]2[CH:52]=[CH:51][CH:50]=[CH:49][N:48]=2)[CH2:39][N:38]1[CH2:53][CH2:54][O:55][C:28]1[CH:27]=[CH:26][C:31]([CH:22]=[O:21])=[CH:30][CH:29]=1

Participants

5

Reactant 3

HCID 19706968HCID 19706968, compoundHCID 19707002HCID 19707002, compoundHCID 54441120HCID 54441120, compound

Product 2

HCID 240BenzaldehydeHCID 19706994HCID 19706994, compound

Procedure

Reactions were carried out in the same manner as in the Preparation Example 3, except that 2-(4-oxo-1-phenyl-1,2,3,4-tetrahydroquinazolin-3-yl)ethanol was replaced by 2-(4-oxo-1-methyl-1,2,3,4-tetrahydroquinazolin-3-yl) ethanol or 2-[4-oxo-1-(2-pyridyl)-1,2,3,4-tetrahydroquinazolin-3-yl]ethanol, to produce 4-[2-(4-oxo-1-methyl-1,2,3,4)-tetrahydroquinazolin-3-yl)ethoxy]benzaldehyde (Compound 4L) and 4-[2-[4-oxo-1-(2-pyridyl)-1,2,3,4-tetrahydroquinazolin-3-yl]ethoxy]benzaldehyde (Compound 4M) , respectively.

Sources & evidence

ORD record
ord-09e8a6ae76494b8397373742dbeb3172
Source dataset
uspto-grants-1998_01
Patent number
US05710152

Reaction notes

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