反应详情

温度

70 °C

To a solution of (+) 1-azabicyclo[3.2.1]octan-6-one (124 g, 1 mol) in ethanol (100 ml) was added a solution of (+) camphorsulfonic acid (232 g, 1.0 mol) in 200 ml ethanol. The mixture was heated to 70° C. and slowly cooled over 2 hours to 5° C. The precipitated crystals were collected by filtration and washed with cold ethanol (3×40 ml). The crude compound was crystallized from ethanol (150 ml) giving the title compound in 57.3 g yield. M.p. 267°-268° C. (decomp.). [α]D =+48° (water).

1. temperatureslowly cooled over 2 hours to 5° C
2. filtrationThe precipitated crystals were collected by filtration
3. washwashed with cold ethanol (3×40 ml)
4. customThe crude compound was crystallized from ethanol (150 ml)