Trimethyl phosphite → 6,7-Dichloro-3-dimethylphosphonomethyl-2-bromoquinoline

Participants

Reaction Steps

A mixture of 6,7-dichloro-2-bromo-3-bromomethylquinoline (0.74 g, 2 mmol) and trimethylphosphite (5 ml) was heated at 80°-90° C. for 2-3h. Then the excess trimethylphosphite was removed in vacuo at 70°-80° C. and the oily residue was made crystalline by treating with hexane-ethyl ether (1:1). The crystalls were collected, washed with toluene and dried in vacuo to give 0.65 g of 6,7-dichloro-3-dimethylphosphonomethyl-2-bromoquinoline.

Provenance & Evidence