反应详情

A mixture of 6,7-dichloro-2-bromo-3-bromomethylquinoline (0.74 g, 2 mmol) and trimethylphosphite (5 ml) was heated at 80°-90° C. for 2-3h. Then the excess trimethylphosphite was removed in vacuo at 70°-80° C. and the oily residue was made crystalline by treating with hexane-ethyl ether (1:1). The crystalls were collected, washed with toluene and dried in vacuo to give 0.65 g of 6,7-dichloro-3-dimethylphosphonomethyl-2-bromoquinoline.

1. temperaturewas heated at 80°-90° C. for 2-3h
2. customThen the excess trimethylphosphite was removed in vacuo at 70°-80° C.
3. additionby treating with hexane-ethyl ether (1:1)
4. customThe crystalls were collected
5. washwashed with toluene
6. customdried in vacuo