反应详情

A mixture of 1,2-dihydro-4-phenyl-2-oxo-3-quinoline carboxylic acid ethyl ester (5 g, 17 mmol), ethanol (20 ml), water (40 ml) and potassium hydroxide (5 g, 89 mmol) was refluxed with heat for 1.5 hours. To the reaction mixture was added 60 ml of 2N-HCl to acidify the mixture to obtain a precipitated crystal by filtration. The crystal obtained was recrystallized from ethanol to give 4.2 g (yield: 92.9%) of the title compound.

1. temperaturewas refluxed
2. temperaturewith heat for 1.5 hours
3. customto obtain a precipitated crystal
4. filtrationby filtration
5. customThe crystal obtained
6. customwas recrystallized from ethanol