Methylamine → HCID 11478636, compound

Participants

Reaction Steps

Using 0.5 g of (Z)-[1-[4-[2-(2-ethyl-1H-imidazol-1-yl)benzoylamino]benzoyl]-4,4-difluoro-2,3,4,5-tetrahydro-1H-1-benzazepin-5-ylidene]acetic acid and 40% methylamine aqueous solution, a similar procedure as in Example 11 was repeated to obtain 425 mg of (Z)-2-(2-ethyl-1H-imidazol-1-yl)-4'-[[4,4-difluoro-5-[(N-methylcarbamoyl)methylene]-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]carbonyl]benzanilide.

Provenance & Evidence