Methylamine → HCID 11478636, compound

HRID 726710Notes

Reaction equation

[CH2:1]([C:3]1[N:4]([C:8]2[CH:41]=[CH:40][CH:39]=[CH:38][C:9]=2[C:10]([NH:12][C:13]2[CH:37]=[CH:36][C:16]([C:17]([N:19]3[C:25]4[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=4/[C:23](=[CH:30]/[C:31]([OH:33])=O)/[C:22]([F:35])([F:34])[CH2:21][CH2:20]3)=[O:18])=[CH:15][CH:14]=2)=[O:11])[CH:5]=[CH:6][N:7]=1)[CH3:2].[CH3:42][NH2:43]>>[CH2:1]([C:3]1[N:4]([C:8]2[CH:41]=[CH:40][CH:39]=[CH:38][C:9]=2[C:10]([NH:12][C:13]2[CH:14]=[CH:15][C:16]([C:17]([N:19]3[C:25]4[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=4/[C:23](=[CH:30]/[C:31](=[O:33])[NH:43][CH3:42])/[C:22]([F:34])([F:35])[CH2:21][CH2:20]3)=[O:18])=[CH:36][CH:37]=2)=[O:11])[CH:5]=[CH:6][N:7]=1)[CH3:2]

Participants

Reactant 2

HCID 6329Methylamine

HCID 11421558HCID 11421558, compound

Product 1

HCID 11478636HCID 11478636, compound

Procedure

Using 0.5 g of (Z)-[1-[4-[2-(2-ethyl-1H-imidazol-1-yl)benzoylamino]benzoyl]-4,4-difluoro-2,3,4,5-tetrahydro-1H-1-benzazepin-5-ylidene]acetic acid and 40% methylamine aqueous solution, a similar procedure as in Example 11 was repeated to obtain 425 mg of (Z)-2-(2-ethyl-1H-imidazol-1-yl)-4'-[[4,4-difluoro-5-[(N-methylcarbamoyl)methylene]-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]carbonyl]benzanilide.

Sources & evidence

ORD record: ord-9c804e9d1da4449ca0d6cd6160bf1238
Source dataset: uspto-grants-1998_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05710150

Reaction notes

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