Cyclopropylamine → HCID 11786689, compound

HRID 726711Notes

Reaction equation

[CH2:1]([C:3]1[N:4]([C:8]2[CH:41]=[CH:40][CH:39]=[CH:38][C:9]=2[C:10]([NH:12][C:13]2[CH:37]=[CH:36][C:16]([C:17]([N:19]3[C:25]4[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=4/[C:23](=[CH:30]/[C:31](O)=[O:32])/[C:22]([F:35])([F:34])[CH2:21][CH2:20]3)=[O:18])=[CH:15][CH:14]=2)=[O:11])[CH:5]=[CH:6][N:7]=1)[CH3:2].[CH:42]1([NH2:45])[CH2:44][CH2:43]1>>[CH:42]1([NH:45][C:31](/[CH:30]=[C:23]2\[C:22]([F:34])([F:35])[CH2:21][CH2:20][N:19]([C:17]([C:16]3[CH:36]=[CH:37][C:13]([NH:12][C:10](=[O:11])[C:9]4[CH:38]=[CH:39][CH:40]=[CH:41][C:8]=4[N:4]4[CH:5]=[CH:6][N:7]=[C:3]4[CH2:1][CH3:2])=[CH:14][CH:15]=3)=[O:18])[C:25]3[CH:26]=[CH:27][CH:28]=[CH:29][C:24]\2=3)=[O:32])[CH2:44][CH2:43]1

Participants

Reactant 2

HCID 69828Cyclopropylamine

HCID 11421558HCID 11421558, compound

Product 1

HCID 11786689HCID 11786689, compound

Procedure

Using 0.5 g of (Z)-[1-[4-[2-(2-ethyl-1H-imidazol-1-yl)benzoylamino]benzoyl]-4,4-difluoro-2,3,4,5-tetrahydro-1H-1-benzazepin-5-ylidene]acetic acid and 0.074 ml of cylopropylamine, a similar procedure as in Example 11 was repeated to obtain 325 mg of (Z)-4'-[[5-[(N-cyclopropylcarbamoyl)methylene]-4,4-difluoro-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]carbonyl]-2-(2-ethyl-1H-imidazol-1-yl) benzanilide.

Sources & evidence

ORD record: ord-a83bd407309343b7b4a125310509120e
Source dataset: uspto-grants-1998_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05710150

Reaction notes

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