HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → beta-[[3-[4-(Aminoiminomethyl)benzyl]aminobenzoyl]amino]-3-pyridinepropanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | Ethyl beta-[[3-[4-(aminoiminomethyl)benzyl]aminobenzoyl]amino]3-pyridine-propanoate | HCID 86751963 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | beta-[[3-[4-(Aminoiminomethyl)benzyl]aminobenzoyl]amino]-3-pyridinepropanoic acid | HCID 67841335 | 86.8% |
Reaction Steps
Ethyl β-[[3-[4-(aminoiminomethyl)benzyl]aminobenzoyl]amino]3-pyridine-propanoate (0.35 g; 0.8 mmoles) was treated with 1N lithium hydroxide and methanol (1:1; 20 ml) for 5 min. Methanol was removed under reduced pressure and the residue was purified by HPLC using acetonitrile/water/trifluoroacetic acid system. The desired fractions were collected and lyophilized to give 290 mg of white material. FAB-MS: MH+ =418.0.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05710166 |
| Source dataset | uspto-grants-1998_01 |
| ORD ID | ord-7868883c590c49b283e7d225b3141d68 |
| Source note | uspto-grants-1998_01 |