HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Lithium Hydroxide → beta-[[3-[4-(Aminoiminomethyl)benzyl]aminopropanoyl]amino]-3-pyridinepropanoic acid
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Lithium Hydroxide | HCID 3939 | — |
| Edukt | Ethyl beta-[[3-[4-(aminoiminomethyl)benzyl]aminopropanoyl]amino]3-pyridinepropanoate | HCID 86751964 | — |
| Lösungsmittel | Methanol | HCID 887 | — |
| Produkt | beta-[[3-[4-(Aminoiminomethyl)benzyl]aminopropanoyl]amino]-3-pyridinepropanoic acid | HCID 67841185 | 77% |
Reaktionsschritte
Ethyl β-[[3-[4-(aminoiminomethyl)benzyl]aminopropanoyl]amino]3-pyridine-propanoate (70 mg) was treated with 1N lithium hydroxide and methanol (1:1; 20 ml) for 5 min. Methanol was removed under reduced pressure and the residue was purified by HPLC using acetonitrile/water/trifluoroacetic acid system. The desired fractions were collected and lyophilized to give 50 mg of white material (77% yield). FAB-MS: MH+ =370.3.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05710166 |
| Quelldatensatz | uspto-grants-1998_01 |
| ORD ID | ord-b4c7c1d48ba342809cccf944166fc8b5 |
| Quellennotiz | uspto-grants-1998_01 |