Lithium Hydroxide → beta-[[3-[4-(Aminoiminomethyl)benzyl]aminopropanoyl]amino]-3-pyridinepropanoic acid

HRID 726721Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 726721
[NH2:1][N:2]=[CH:3][C:4]1[CH:29]=[CH:28][C:7]([CH2:8][NH:9][CH2:10][CH2:11][C:12]([NH:14][CH:15]([C:22]2[CH:23]=[N:24][CH:25]=[CH:26][CH:27]=2)[CH2:16][C:17]([O:19]CC)=[O:18])=[O:13])=[CH:6][CH:5]=1.[OH-].[Li+]>CO>[NH2:1][N:2]=[CH:3][C:4]1[CH:5]=[CH:6][C:7]([CH2:8][NH:9][CH2:10][CH2:11][C:12]([NH:14][CH:15]([C:22]2[CH:23]=[N:24][CH:25]=[CH:26][CH:27]=2)[CH2:16][C:17]([OH:19])=[O:18])=[O:13])=[CH:28][CH:29]=1

Komponenten

4

Edukt 2

HCID 3939Lithium HydroxideHCID 86751964Ethyl beta-[[3-[4-(aminoiminomethyl)benzyl]aminopropanoyl]amino]3-pyridinepropanoate

Produkt 1

HCID 67841185beta-[[3-[4-(Aminoiminomethyl)benzyl]aminopropanoyl]amino]-3-pyridinepropanoic acidAusbeute 77 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

Ethyl β-[[3-[4-(aminoiminomethyl)benzyl]aminopropanoyl]amino]3-pyridine-propanoate (70 mg) was treated with 1N lithium hydroxide and methanol (1:1; 20 ml) for 5 min. Methanol was removed under reduced pressure and the residue was purified by HPLC using acetonitrile/water/trifluoroacetic acid system. The desired fractions were collected and lyophilized to give 50 mg of white material (77% yield). FAB-MS: MH+ =370.3.

Aufarbeitung

  1. customMethanol was removed under reduced pressure
  2. customthe residue was purified by HPLC
  3. customThe desired fractions were collected

Quellen und Nachweise

ORD-Eintrag
ord-b4c7c1d48ba342809cccf944166fc8b5
Quelldatensatz
uspto-grants-1998_01
Patentnummer
US05710166

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