1-Phenethylamine, (+)- → HCID 53842783, compound

HRID 726873Notes

Reaction equation

HRID 726873 reaction equation
[CH3:1][C:2]([CH3:9])([CH3:8])[C:3](=O)[C:4]([NH2:6])=[O:5].[C:10]1([C@H:16]([NH2:18])[CH3:17])[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>>[CH3:1][C:2]([CH3:9])([CH3:8])[C:3](=[N:18][C@@H:16]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[CH3:17])[C:4]([NH2:6])=[O:5]

Participants

3

Reactant 2

HCID 6431891-Phenethylamine, (+)-HCID 12922742Trimethylpyruvic acid amide

Product 1

HCID 53842783HCID 53842783, compoundYield 67%

Procedure

The procedure described under n) was carried out using 5.0 g of 3,3-dimethyl-2-oxo-butyramide and 10.0 g of (R)-1-phenylethylamine. After a single crystallization from hexane there were isolated 6.0 g (67%) of (R)-3,3-dimethyl-2-(1-phenylethylimino)-butyramide of melting point 100°-101° C. [α]=+61.4 (c=0.8, CHCl3).

Workup

  1. customAfter a single crystallization from hexane

Sources & evidence

ORD record
ord-d05512a1c5294de4986ce87d31476a47
Source dataset
uspto-grants-1998_01
Patent number
US05710322

Reaction notes

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