反应详情

温度

60 °C

8-Chloro-4-iodo-3-methoxy-2,5-dioxo-2,5-dihydro-1H-benz[b]azepine (0.4 g) was treated with diethylamine (20 mL). The mixture was sealed in a pressure vessel and heated to 60° C. for 17 hours. The reaction mixture was concentrated to a brown solid which was recrystallized from hot ethyl acetate. The solid was filtered, washed and air dried to give the title compound as a yellow solid; NMR: 5.70 (s,1); MS: m/z=279(M+1).

1. customThe mixture was sealed in a pressure vessel
2. concentrationThe reaction mixture was concentrated to a brown solid which
3. customwas recrystallized from hot ethyl acetate
4. filtrationThe solid was filtered
5. washwashed
6. customair dried