4-Phenylcyclohexanone → HCID 483228, compound

HRID 727166Notes

Reaction equation

HRID 727166 reaction equation
[C:1]([NH:3][C:4]([NH2:6])=[NH:5])#[N:2].[C:7]1([CH:13]2[CH2:18][CH2:17][C:16](=O)[CH2:15][CH2:14]2)[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>>[NH2:5][C:4]1[N:3]=[C:1]([NH2:2])[C:15]2[CH2:14][CH:13]([C:7]3[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=3)[CH2:18][CH2:17][C:16]=2[N:6]=1

Participants

3

Reactant 2

HCID 786054-PhenylcyclohexanoneHCID 178418324HCID 178418324, compound

Product 1

HCID 483228HCID 483228, compound

Procedure

This compound was prepared in a manner analogous to that of Example 1, using 4.2 grams (0.05 mole) of cyanoguanidine and 13.1 grams (0.08 mole) of 4-phenylcyclohexanone. The crude product was recrystallized from ethanol, yielding 2,4-diamino-6-phenyl-5,6,7,8-tetrahydroquinazoline, mp 223°-226° C. The NMR spectrum was consistent with the proposed structure.

Workup

  1. customThis compound was prepared in a manner analogous to that of Example 1
  2. customThe crude product was recrystallized from ethanol

Sources & evidence

ORD record
ord-5e09201d69a8448fbe8aebde8306b0c8
Source dataset
uspto-grants-1998_01
Patent number
US05712281

Reaction notes

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