Chlorotrimethylsilane → HCID 19705267, compound

HRID 727173Notes

Reaction equation

HRID 727173 reaction equation
[F:1][C:2]1([F:15])[C:6]([F:8])([F:7])[C:5]2[CH:9]=[CH:10][CH:11]=[C:12]([CH2:13]O)[C:4]=2[O:3]1.[Br-:16].[Li+].C[Si](Cl)(C)C>C(#N)C>[F:1][C:2]1([F:15])[C:6]([F:8])([F:7])[C:5]2[CH:9]=[CH:10][CH:11]=[C:12]([CH2:13][Br:16])[C:4]=2[O:3]1

Participants

5

Reactant 3

HCID 6397ChlorotrimethylsilaneHCID 82050Lithium BromideHCID 197052752,2,3,3-Tetrafluoro-2,3-dihydrobenzofuran-7-ylmethanol

Product 1

HCID 19705267HCID 19705267, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

This compound is prepared in a manner analogous to that of Step A of Example 5, using 11.1 grams (0.05 mole) of 2,2,3,3-tetrafluoro-2,3-dihydrobenzofuran-7-ylmethanol, 8.7 grams (0.1 mole) of lithium bromide, and 13.5 grams (0.125 mole) of trimethylsilyl chloride in 100 mL of acetonitrile, yielding 2,2,3,3-tetrafluoro-2,3-dihydrobenzofuran-7-ylmethyl bromide.

Workup

  1. customThis compound is prepared in a manner analogous to that of Step A of Example 5

Sources & evidence

ORD record
ord-082d7d0504ef4a1b99f32002c5d8ba74
Source dataset
uspto-grants-1998_01
Patent number
US05712281

Reaction notes

Loading…