4-(2,2,3,3-Tetrafluoro-2,3-dihydrobenzofuran-7-ylmethyl)cyclohexanone → 2,4-Diamino-6-(2,2,3,3-tetrafluoro-2,3-dihydrobenzofuran-7-ylmethyl)-5,6,7,8-tetrahydroquinazoline

HRID 727178Notes

Reaction equation

HRID 727178 reaction equation
[F:1][C:2]1([F:21])[C:6]([F:8])([F:7])[C:5]2[CH:9]=[CH:10][CH:11]=[C:12]([CH2:13][CH:14]3[CH2:19][CH2:18][C:17](=O)[CH2:16][CH2:15]3)[C:4]=2[O:3]1.[C:22]([NH:24][C:25]([NH2:27])=[NH:26])#[N:23]>C(OCCOCCO)C>[NH2:27][C:25]1[N:24]=[C:22]([NH2:23])[C:18]2[CH2:19][CH:14]([CH2:13][C:12]3[C:4]4[O:3][C:2]([F:21])([F:1])[C:6]([F:8])([F:7])[C:5]=4[CH:9]=[CH:10][CH:11]=3)[CH2:15][CH2:16][C:17]=2[N:26]=1

Participants

4

Reactant 2

HCID 197052664-(2,2,3,3-Tetrafluoro-2,3-dihydrobenzofuran-7-ylmethyl)cyclohexanoneHCID 178418324HCID 178418324, compound

Product 1

HCID 197052082,4-Diamino-6-(2,2,3,3-tetrafluoro-2,3-dihydrobenzofuran-7-ylmethyl)-5,6,7,8-tetrahydroquinazoline

Reagents, catalysts & solvents 1

HCID 8146Diethylene Glycol Monoethyl EtherSolvent

Procedure

This compound is prepared in a manner analogous to that of Example 1, using 3.9 grams (0.013 mole) of 4-(2,2,3,3-tetrafluoro-2,3-dihydrobenzofuran-7-ylmethyl)cyclohexanone and 1.2 grams (0.014 mole) of cyanoguanidine in 2-(2-ethoxyethoxy)ethanol, yielding 2,4-diamino-6-(2,2,3,3-tetrafluoro-2,3-dihydrobenzofuran-7-ylmethyl)-5,6,7,8-tetrahydroquinazoline.

Workup

  1. customThis compound is prepared in a manner analogous to that of Example 1

Sources & evidence

ORD record
ord-38f53b407f404454a5a1ef0c2d4c2514
Source dataset
uspto-grants-1998_01
Patent number
US05712281

Reaction notes

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