1-(3-Chlorophenyl)ethanone → Benzenemethanol, 3-chloro-.alpha.,.alpha.-dimethyl-

HRID 727180Notes

Reaction equation

HRID 727180 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]([CH3:10])=[O:9])[CH:5]=[CH:6][CH:7]=1.[CH3:11][Mg]Br>O1CCCC1>[Cl:1][C:2]1[CH:3]=[C:4]([C:8]([OH:9])([CH3:11])[CH3:10])[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 149331-(3-Chlorophenyl)ethanoneHCID 178418573HCID 178418573, compound

Product 1

HCID 593110Benzenemethanol, 3-chloro-.alpha.,.alpha.-dimethyl-

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

This compound is prepared in a manner analogous to that of Step A of this Example, using 13.9 grams (0.09 mole) of methyl 3-chlorophenyl ketone and 33.3 mL of methylmagnesium bromide (3.0M in diethyl ether) in 50 mL of dry tetrahydrofuran, yielding 2-(3-chlorophenyl)propan-2-ol.

Workup

  1. customThis compound is prepared in a manner analogous to that of Step A of this Example

Sources & evidence

ORD record
ord-22495671f959406c98dda1a3261ec06e
Source dataset
uspto-grants-1998_01
Patent number
US05712281

Reaction notes

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