Hydrazine hydrate (1:1) → HCID 178426518, compound

HRID 727226Notes

Reaction equation

HRID 727226 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([NH:9][C:10]([C:12]2[CH:17]=[N:16][CH:15]=[CH:14][N:13]=2)=S)[CH:3]=1.O.[NH2:19][NH2:20]>C(O)C>[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([NH:9][C:10](=[N:19][NH2:20])[C:12]2[CH:17]=[N:16][CH:15]=[CH:14][N:13]=2)[CH:3]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 22105793HCID 22105793, compound

Product 1

HCID 178426518HCID 178426518, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To 1 g of compound of Example 24 dissolved in 30 ml of ethanol is added 0.6 ml of hydrazine monohydrate and the mixture is left stirring for 30 minutes at room temperature. The reaction medium is then poured into ice-water. It is stirred vigorously for 20 minutes. The mixture is filtered and dried and the residue is recrystallized from isopropyl ether.

Workup

  1. waitthe mixture is left
  2. stirringIt is stirred vigorously for 20 minutes
  3. filtrationThe mixture is filtered
  4. customdried
  5. customthe residue is recrystallized from isopropyl ether

Sources & evidence

ORD record
ord-819a7b8b0498449d92802c55c2ef084e
Source dataset
uspto-grants-1998_01
Patent number
US05712294

Reaction notes

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