関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | 2-Thiopheneboronic acid | HCID 2733960 | — |
| 反応物 | 2-Amino-5-bromo-3-iodobenzenesulphonic acid | HCID 18919385 | — |
| 触媒 | HCID 178418397 | HCID 178418397 | — |
| 溶媒 | 1,2-Dimethoxyethane | HCID 8071 | — |
| 生成物 | HCID 23687032 | HCID 23687032 | — |
反応手順
A mixture of 36 g (95.3 mmol) of 2-amino-5-bromo-3-iodobenzenesulphonic acid and 12.2 g (95.3 mmol) of 2-thienylboronic acid in 140 ml of 1,2-dimethoxyethane in the presence of 5.5 g of tetrakis(triphenylphosphine)palladium (0) and 30.3 g of sodium carbonate is heated at 70°-75° C. for 8.5 hours. The solvent is evaporated off under vacuum, the mixture is cooled to 0° C. and washed with water to pH=7, and the residue is then taken up in an ether/ethanol mixture (95:5).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05712393 |
|---|
| 出典データセット | uspto-grants-1998_01 |
|---|
| ORD ID | ord-2536f492f1304a019258011950e887e6 |
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| 出典メモ | uspto-grants-1998_01 |
|---|
