反应详情

To a solution containing 7.6 g (20 mmol) of 2-amino-5-bromo-3-iodobenzenesulphonic acid and 4.8 ml (20 mmol) of tributylamine in 20 ml of dichloromethane is added dropwise, at 0° C. under a nitrogen atmosphere, a solution of dichlorotriphenylphosphorane (9.7 g (37.5 mmol) in 45 ml of dichloromethane). The mixture is brought to room temperature, stirring is continued for 18 hours and the product is purified by chromatography on a column of silica gel, eluting with a dichloromethane/pentane mixture (2:8).

1. additionis added dropwise, at 0° C. under a nitrogen atmosphere
2. customis brought to room temperature
3. customthe product is purified by chromatography on a column of silica gel
4. washeluting with a dichloromethane/pentane mixture (2:8)