HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 3-(2-Methylpropyl)-2-oxo-1-(2-phenylethyl)-alpha-[2-(2-thienylthio)ethyl]-3-pyrrolidineacetic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | tert-Butyl 3-(2-Methylpropyl)-2-oxo-1-(2-phenylethyl)-alpha-[2-(2-thienylthio)ethyl]-3-pyrrolidineacetate | HCID 19705522 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-(2-Methylpropyl)-2-oxo-1-(2-phenylethyl)-alpha-[2-(2-thienylthio)ethyl]-3-pyrrolidineacetic Acid | HCID 19705469 | 96% |
Reaction Steps
A solution of tert-butyl 3-(2-methylpropyl)-2-oxo-1-(2-phenylethyl)-α-[2-(2-thienylthio)ethyl]-3-pyrrolidineacetate (338 mg, 0.674 mmol), trifluoroacetic acid (3 mL), and CH2Cl2 (3 mL) is stirred at 0° C. for 15 minutes and at room temperature for 1.5 hour. Concentration and aqueous workup (CH2Cl2, MgSO4) gives 287 mg (96%) of the title compound as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05712300 |
| Source dataset | uspto-grants-1998_01 |
| ORD ID | ord-ec60b4947d5c4e5a9970e75a4a9ef964 |
| Source note | uspto-grants-1998_01 |