反应详情

A solution of tert-butyl 3-(2-methylpropyl)-2-oxo-1-(2-phenylethyl)-α-[2-(2-thienylthio)ethyl]-3-pyrrolidineacetate (338 mg, 0.674 mmol), trifluoroacetic acid (3 mL), and CH2Cl2 (3 mL) is stirred at 0° C. for 15 minutes and at room temperature for 1.5 hour. Concentration and aqueous workup (CH2Cl2, MgSO4) gives 287 mg (96%) of the title compound as a colorless oil.

1. concentrationConcentration and aqueous workup (CH2Cl2, MgSO4)