反应详情

温度

40 °C

TMSCl (2.2 mL, 18 mmol) is added dropwise to a solution of 3-(2-methylpropyl)-2-pyrrolidinone (2.25 g, 15.9 mmol), triethylamine (2.7 mL, 19 mmol), and toluene (16 mL) at room temperature. The mixture is heated at 40° C. for 3 hours and diluted with hexane (50 mL). After stirring for 10 minutes at 0° C., the mixture is filtered and the filtrate concentrated. Distillation (1 mm, 62°-68° C.) of the residue gives 2.40 g (71%) of the title compound as an oil.

1. filtrationthe mixture is filtered
2. concentrationthe filtrate concentrated
3. distillationDistillation (1 mm, 62°-68° C.) of the residue