Methylamine → HCID 53731361, compound

HRID 727541Notes

Reaction equation

HRID 727541 reaction equation
[CH3:1][CH:2]([CH3:19])[CH2:3][C:4]1([C:16]([CH3:18])=[CH2:17])[CH2:8][CH2:7][N:6]([CH2:9][C:10](OCC)=[O:11])[C:5]1=[O:15].[CH3:20][NH2:21]>CCO>[CH3:20][NH:21][C:10](=[O:11])[CH2:9][N:6]1[CH2:7][CH2:8][C:4]([CH2:3][CH:2]([CH3:19])[CH3:1])([C:16]([CH3:18])=[CH2:17])[C:5]1=[O:15]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 54302501HCID 54302501, compound

Product 1

HCID 53731361HCID 53731361, compoundYield 85%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Ethyl 3-(2-methylpropyl)-2-oxo-3-(propen-2-yl)-1-pyrrolidineacetate (500 mg, 1.87 mmol) is stirred in a saturated solution of methylamine in EtOH (50 mL) at room temperature overnight. The solution is concentrated and purified by column chromatography (1:12:8 v/v CH2Cl2 :EtOAc:hexane) to give 401 mg (85%) of the title compound as an oil.

Workup

  1. concentrationThe solution is concentrated
  2. custompurified by column chromatography (1:12:8 v/v CH2Cl2 :EtOAc:hexane)

Sources & evidence

ORD record
ord-e497a7cdc5fd49cc8850f8c619955b68
Source dataset
uspto-grants-1998_01
Patent number
US05712300

Reaction notes

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