Hydrochloric Acid → HCID 178465582, compound

HRID 727718Notes

Reaction equation

HRID 727718 reaction equation
[C:1]([NH:4][CH:5]1[CH2:8][N:7]([C:9]([C@@H:11]2[CH2:15][C@H:14]([S:16][C:17]3[C@H:18]([CH3:31])[C@@H:19]4[C@@H:26]([C@H:27]([OH:29])[CH3:28])[C:25](=[O:30])[N:20]4[C:21]=3[C:22]([OH:24])=[O:23])[CH2:13][NH:12]2)=[O:10])[CH2:6]1)(=[NH:3])[CH3:2].[ClH:32]>O>[ClH:32].[C:1]([NH:4][CH:5]1[CH2:6][N:7]([C:9]([C@@H:11]2[CH2:15][C@H:14]([S:16][C:17]3[C@H:18]([CH3:31])[C@@H:19]4[C@@H:26]([C@H:27]([OH:29])[CH3:28])[C:25](=[O:30])[N:20]4[C:21]=3[C:22]([OH:24])=[O:23])[CH2:13][NH:12]2)=[O:10])[CH2:8]1)(=[NH:3])[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178465581HCID 178465581, compound

Product 1

HCID 178465582HCID 178465582, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

0.40 g of (1R,5S,6S)-2-[(2S,4S)-2-(3-Acetimidoylaminoazetidin-1-ylcarbonyl)pyrrolidin-4-ylthio]-6-[(1R)-1-hydroxyethyl]-1-methyl-1-carbapen-2-em-3-carboxylic acid (prepared as described in Example 122) was dissolved in 20 ml of cold water. 0.88 ml of 1N aqueous hydrochloric acid was added to the resulting solution, and the mixture was freeze-dried, to obtain 400 mg of the title compound as a colorless powder.

Workup

  1. customthe mixture was freeze-dried

Sources & evidence

ORD record
ord-6fca1a5fabdf4263b7216250814f31f0
Source dataset
uspto-grants-1998_01
Patent number
US05712267

Reaction notes

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