Phenol → 2,2,2-Trifluoro-1-(4-hydroxyphenyl)ethanone

HRID 727761Notes

Reaction equation

[C:1]1([OH:7])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[F:8][C:9]([F:14])([F:13])[C:10](Cl)=[O:11]>>[F:8][C:9]([F:14])([F:13])[C:10]([C:4]1[CH:5]=[CH:6][C:1]([OH:7])=[CH:2][CH:3]=1)=[O:11]

Participants

Reactant 2

HCID 996Phenol

HCID 61106Trifluoroacetyl chloride

Product 1

HCID 114468182,2,2-Trifluoro-1-(4-hydroxyphenyl)ethanone

Procedure

0.1 mol of phenol and 0.1 mol of trifluoroacetyl chloride are reacted analogously to Example 4 to give 4-trifluoroacetylphenol. The latter is esterified using carboxylic acids and DCC. With p-pentylbenzoic acid, 4-trifluoroacetylphenyl pentylbenzoate, mp. 27° C., Δε=26.7, is obtained.

Sources & evidence

ORD record: ord-7c874369ad0347f4bf10c54a22bc98c0
Source dataset: uspto-grants-1991_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05045229

Reaction notes

Loading…