Water → HCID 19825142, compound

HRID 727828Notes

Reaction equation

HRID 727828 reaction equation
[CH3:1][N:2]([CH3:22])[S:3]([N:6]1[CH:10]=[C:9]([C:11](=[O:21])[C:12]2[C:17]([Cl:18])=[CH:16][C:15]([Cl:19])=[CH:14][C:13]=2[Cl:20])[N:8]=[CH:7]1)(=[O:5])=[O:4].[H-].[Al+3].[Li+].[H-].[H-].[H-].O.[OH-].[Na+]>O1CCCC1>[CH3:1][N:2]([CH3:22])[S:3]([N:6]1[CH:10]=[C:9]([CH:11]([OH:21])[C:12]2[C:17]([Cl:18])=[CH:16][C:15]([Cl:19])=[CH:14][C:13]=2[Cl:20])[N:8]=[CH:7]1)(=[O:4])=[O:5]

Participants

6

Reactant 4

HCID 962Water2×HCID 14798Sodium HydroxideHCID 19825139HCID 19825139, compoundHCID 21226445Aluminium lithium hydride

Product 1

HCID 19825142HCID 19825142, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

1-(Dimethylsulphamoyl)-4-(2,4,6-trichlorobenzoyl)imidazole (2.6 g) in dry tetrahydrofuran (15 ml) was added over 30 seconds to lithium aluminium hydride (110 mg) in dry tetrahydrofuran (15 ml) with cooling. The mixture was stirred at 5° for 30 minutes. Water (0.110 ml ), aqueous sodium hydroxide (15%: 0.110 ml) and water (0.330 ml) were added and the mixture stirred for 15 minutes at room temperature. The mixture was filtered and the precipitate washed with tetrahydrofuran. The filtrate and washings were evaporated under reduced pressure and the residue washed with diisopropyl ether and dried under reduced pressure to give 1-(dimethylsulphamoyl)-4-(2,4,6-trichloro-α-hydroxybenzyl)imidazole, as an off white solid. To this product (1.92 g) in dry tetrahydrofuran (40 ml) was added sodium hydride (170 mg; 80g in oil), with stirring, under nitrogen. Trimethylsilyl chloride (0.7 ml) was added to this mixture at 30° to give the trimethyl silyl ether. The mixture was then cooled to - 70° and butyllithium (2.2 ml; 2 5M in hexane) added. The mixture was stirred at -78° for 30 minutes, dimethylformamide (0.5 ml) added and the mixture allowed to warm to room temperature. The mixture was poured into ice/water, stirred for 30 minutes and the solid collected and dried to give crude 1-(dimethylsulphamoyl)-2-formyl-4-[(2,4,6-trichloro-α-(trimethylsilyloxy)benzyl]imidazole. This was then then treated with hydroxylamine hydrochloride in a similar manner to step (b) in Example 1, to give crude 1-(dimethylsulphamoyl)-2-(hydroxyiminomethyl)-4-(2,4,6-trichloro-α-hydroxybenzyl)imidazole. This was then treated with trifluoroacetic anhydride in a similar manner to step (c) in Example 1, to give crude 2-cyano-1-(dimethylsulphamoyl)-4-(2,4,6-trichloro-α-hydroxybenzyl)imidazole, as an off white solid.

Workup

  1. temperaturewith cooling
  2. stirringthe mixture stirred for 15 minutes at room temperature
  3. filtrationThe mixture was filtered
  4. washthe precipitate washed with tetrahydrofuran
  5. customThe filtrate and washings were evaporated under reduced pressure
  6. washthe residue washed with diisopropyl ether
  7. customdried under reduced pressure

Sources & evidence

ORD record
ord-cca85ea4d4344734aaea55dd318fe475
Source dataset
uspto-grants-1991_09
Patent number
US05045557

Reaction notes

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